Mike Monteiro and Katie Gillum of Mule Design have been doing this podcast for 3 episodes now, and I find it infinitely interesting, tangents and all. Maybe it's just satisfying the long-too-dormant right-side of my brain, but I think it's worth a listen for anyone even remotely involved in creating things for people to use, software, websites, toasters, or otherwise.

http://5by5.tv/mistakes